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In pre-clinical laboratory models, MOTS-c has demonstrated a wide range of effects relevant to metabolic science, exercise physiology, and longevity research: Reverses diet-induced insulin resistance — studies have shown MOTS-c can improve insulin sensitivity in skeletal muscle in high-fat diet and obesity models Improves glucose metabolism — shown to lower fasting blood glucose levels across multiple diabetic animal models (T1D, T2D, gestational diabetes) Enhances physical performance — pre-clinical research demonstrated significantly improved exercise capacity in young, middle-aged, and old mice following MOTS-c treatment Reduces age-related muscle decline — late-life intermittent MOTS-c treatment (3x/week) increased physical capacity and healthspan markers in aged mouse models Supports cardiac function — research has observed an 8% reduction in left ventricular wall thickness in treated diabetic groups, with improvements in cardiac energy metabolism Liver steatosis models — studies in Cell Reports (2024) found MOTS-c treatments reduced NASH-diet-induced liver steatosis, apoptosis, inflammation, and fibrosis Pancreatic islet protection — MOTS-c has been studied for its role in reducing pancreatic islet senescence and improving glucose intolerance in diabetes models Oxidative stress regulation — acts on NRF2 and antioxidant response elements (ARE), enhancing cellular resistance to oxidative damage Bone metabolism — emerging research has explored MOTS-c’s role in osteoblast and osteoclast regulation in bone remodelling studies What Do Studies Say About MOTS-c Peptide
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